< PreviousWith this in mind, Lingwood providesORKI, a fully automated decoring,peeling and top and bottom cutter. Thepeeler is capable of handling oranges,kiwis and grapefruit, and all thatremains to be done is to cut the fruitinto pieces. When peeling theseproducts, it’s important to adapt tovariations in peel thickness.Maximum fruit yield can onlybe obtained by taking thesevariations into account andadjusting the peelingsystem. ORKI can do that by utilising its uniquevariable peel thickness mechanism.A further bonus with these new machines comes asthey often ensure exceptional energy efficiency. Thecurrent Bizerba slicers, for example, need onlyroughly 50% of the energy which conventionalmodels consume, with one recent device onlyneeding approximately eighty watts per hour.This also helps cut costs.The big savings come as the motor onlyuses the power required for the necessaryoutput. An item which is easy to slice doesn’tneed the full motor power and, therefore, thefull torque doesn’t have to be used. Duringidling mode, the devices need approximately45% less energy than conventional machinesand, in stand-by mode, powerconsumption is even as lowas zero watts, withouteven a residual current.These machines alsoheat up less, soventilation holes atthe bottom are nolonger necessary.Since the surface isnow fully closed, liquids,residues of product to beSLICING & DICINGThe increased speed across the production process has led tochanges in the way products are sliced, diced and cut. It’s certainlyeasier than ever to ensure products are cut accurately and quickly,but this change has also coincided with the increased interest innatural ingredients, with consumers looking for products thatcontinue to emphasise their “home-made” nature. The new breedof slicing, dicing and cutting machinery can assist in this regard.As Lingwood Food Processing Machinery point out, producingappetising, high quality prepared fruit requires the machinery topeel the raw material effectively while ensuring the cell structureof the product is not damaged. The perfect end result is acleanly peeled product that requires little or no “re-working” and can comfortably last the required shelflife after packaging.Improved slicing and dicing technology is offering exceptional efficiencyThe current Bizerba slicers such as theValidoline VSC 280 offer exceptionalenergy efficiencyCurrent slicersneed only roughly50% of the energywhich conventionalmodels consume40 Food & Drink Internationalwww.fdiforum.netCutting costs40-42:Layout 1 25/7/14 09:41 Page 1Food & Drink International 41www.fdiforum.netsliced and dust can no longer reach the interior of the device. Atthe same time, heat is not dissipated into the environment or intoproducts in the storage area. As a result, this development doesnot only reduce electricity costs but also ensures a higher degreeof hygiene.Slicing equipment is not just required in the productionprocess, but also closer to the consumer in butchers, delicatessensand other retailers. As with the production process they havebenefited from consolidation which means the process can besped up effectively, and Bizerba have launched a weighing andslicing machine with calibrated scales at Euroshop. TheValidoline Flex means sausage, cheese, meat, vegetables, breadand other foods can be sliced and weighed in one action. Thisallows counter staff to serve continuously, in constant sight of thecustomer, who in turn are able to clearly follow their goods fromslicing, to weighing to packing. This means that they can becertain that the amount weighed is exactly what has just beensliced.Such a system also allows customers to be assured hygiene is atop priority, and indeed this has been a major driver ofinnovation across the sector. The cutting process has previouslyinvolved a large number of flashpoints whereby contaminationcan occur – for example, during the loading of the slicer, duringperiods when they need to correct the weight and position of theproduct and during in-feeding into the packaging tray. This isoften no longer the case as these processes are now almostBHJ Ingredients’ SCANPRO BE50 provides technical benefitssuch as improved texture andslicing combined with reducedcook loss42 The Bizerba A550 Automac Slicer can weigh each slice directly as itis sliced and adjust the thickness to give accurate poron weightswith the ability to save up to 15% on giveaway - these are directmonetary savings to youIf you slice, then as the number one Slicer Manufacturer in the world,Bizerba can offer a consultave approach to ensure you are gengthe best for your businessContact us to see how Bizerba Slicers can benefit your business01908 682740 info@bizerba.co.uk www.bizerba.com40-42:Layout 1 25/7/14 09:41 Page 242 Food & Drink Internationalwww.fdiforum.netSLICING & DICINGFlexibility fromLingwoodThe GS range of processingmachinery supplied by Lingwood FoodServices offers the highest levels offlexibility with a high capacity andexcellent cut quality for salad, meat andfish preparation.The recently developed GS20 beltcutting machine is equipped with aconveyor belt of 250mm wide with theproven “downholder” system foraccurate, consistent feed of product intothe blade. The feeding belt has beendesigned to handle whole heads oflettuce or cabbage. The GS20 buildsupon the strengths of the GS10 whichhas sold over 2500 machines worldwide but can now achievethroughputs of up to 2000kg per hour on salads.The GS range is equally as flexible when shredding meat andslicing fish.Key features are the precise product guidance until point of cuttingand the digital in-motion cutting size adjustment from 1 to 50mm(with three blades).Individually definable programs can be stored and selected by thesimple use of the control buttons. Indicator lights indicate the statusof the safety sensors. A new locking system combined with a newbelt cover creates additional safety in the area of the knife.If you are looking for a complete solution in processing yourproducts in the most efficient and cost effective way and stillachieving the highest quality of presentation, Lingwood FoodServices are the ideal company to fulfil your requirements. Customerdemonstrations on various products can be arranged at Lingwood’stest facility in Stowmarket.Call 01449 771202, visit www.lingwood.net or email Sales@lingwood.net for more details.completely automated sothe amount of manualhandling has been reducedto virtually nothing.Some companies havelooked towards other options toensure a cleaner, more accurate andmore efficient cut. Developments in acoustictechnology have introduced ultrasound in the slicing process,based around high frequency vibrations ensuring continuedacceleration and deceleration of the blade that allows for a muchcleaner cut, particularly in sticky products. Waterjet cutting isalso becoming more common, especially in the frozen sectorwhere it’s not always possible to use conventional methods and,instead, intensive pump systems are used to power high pressurewater cutters.Such is the importance of accuracy that new ingredients arenow being produced with improved slicing and dicingcapabilities very much in mind. BHJ Ingredients’ heat stablefunctional beef blend, for example, has been created specificallyfor use in ground beef recipes. SCANPRO BE 50 providesproven technical benefits such as improved texture and slicingcombined with reduced cook loss, and with its heat stablequalities, is of particular interest to meat manufacturersprocessing doner kebab type products where structure, textureand slicing are fundamental.With concerns over excessive product giveaway and the needfor more accurate labelling, more effective slicing, dicing andcutting equipment is proving hugely valuable for manufacturers,retailers and consumers alike.PHOTO: SHUTTERSTOCK.COM/ANGELO GILARDELLIDevelopmentsin acoustictechnology haveintroduced ultrasound in theslicing process40-42:Layout 1 25/7/14 09:41 Page 3Your guide to the pharmaceutical world PharmaBUSINESS INTERNATIONALThe total packageFrom development to dispensingThe total packageFrom development to dispensingwww.pbiforum.net43:Layout 1 25/7/14 09:07 Page 1UCB celebrates ten years inthe UKUCB is celebrating tenyears of scientificexcellence, extensive UKR&D local investment andworld class drug discoveryand development, followingthe company’s acquisitionof Celltech in 2004. Dr Roch Doliveux, UCB’sChief Executive Officer, says, “By bringing together Celltech and UCB we have pushed the boundaries of science todiscover breakthrough medicines that can improve the lives of millions of people across the globe. To that end, UCBhas continuously been investing significantly in R&D. In 2013 our company had the highest R&D spend per employeeamongst top European companies across all sectors and UCB has now the second most productive late stagepipeline of the biopharma industry.” Since the acquisition of Celltech, UCB has significantly increased its annual UK R&D expenditure from £84 milliona year in 2003 to £142 million in 2012 – making it one of the UK’s leading bio-pharmaceutical R&D investors.44Pharma Business International www.pbiforum.netWelcomeBeatson Clark’s new machine caps it allLeading glass manufacturer Beatson Clark can now supply pharmaceutical bottles pre-cappedthanks to an £80,000 investment.A new Groninger six-head capping machine is now in operation at the company’s Rotherhamsite. The equipment will allow Beatson Clark to fulfil a contract with a major high street chemist tosupply pre-capped alpha sirops, continental winchesters and bespoke round bottles. The machineapplies a 28mm Mediloc cap to glass bottles and can process up to 180 containers per minute.Lynn Sidebottom, Marketing Director at Beatson Clark, says, “Safety is a paramount concern forpharmacists and it’s essential that the correct cap is applied to the bottle. Certain pharmaceuticalproducts need to be child-safe and ensuring the correct cap is used also reduces the risk ofcontamination during storage.”Beatson Clark’s new capping machine has an associated UV ink jet coding system which appliesa date/time stamp code on both the cap and the container for traceability.From development todispensingWelcome to this special supplement from Pharma BusinessInternational. As the sister publication of Food & DrinkInternational, it offers the same mix of the latest news, incisiveopinion and valuable editorial covering the whole of thepharmaceuticals sector – from development to dispensing. Asmany food and drink companies are looking towards the sectoras a potential growth market, Pharma Business Internationalis your complete guide to entering this exciting area.If you like what you see over the next fewpages, visit www.pbiforum.net for moreinformation and to check out the latestissue!Hanovia ensures safety invaccine production baseUV disinfection specialist Hanovia has supplied three UV water disinfectionsystems to the Institute of Medical Biology of the Chinese Academy of Sciences inKunming.The PharmaLine PQL units destroy any unwanted microorganism in the purifiedwater used in the production of vaccines. Moreover, these systems can display theverified ultraviolet irradiation dose online, further reducing the risk of microbialcontamination. Shen Feng, the senior engineer and water treatment equipment expert at theInstitute, says, “Compared with other UV disinfection systems, Hanovia’sPharmaLine PQL offers validated disinfection that has been certified by anindependent third party. It also displays the UV dose online, meeting the stringentrequirements of the pharmaceutical industry for verification and risk management.”UV kills 99.9% of the microorganisms, ensuring the concentration in purifiedwater remains at an extremely low level. UV also does not produce any unwanteddisinfection by-products that might contaminate the purified water downstream.44-49:Layout 1 25/7/14 09:38 Page 1Pharma Business International 45www.pbiforum.netLatest newsNovasep passesFDA inspectionson two sitesNovasep, a leading supplier ofservices and technologies to the lifescience industries, has successfullycompleted FDA pre-approvalinspections carried out at two of itssites in France.Novasep, whose CEO MichelSpagnol is pictured, is now anauthorised producer of a newmolecular entity already approved inthe US. The inspection concerned amulti-site project Novasep managesfor synthesising and purifying akinase inhibitor active ingredient.The FDA inspections took placeduring June at Novasep’s Chasse-sur-Rhone and Pompey sites inFrance. The Chasse-sur-Rhone site isresponsible for the synthesis of latestage intermediates and the activepharmaceutical ingredient, while thePompey site takes charge of the lastpurification step.Thierry Van Nieuwenhove,president of the Synthesis BU atNovasep, says, “We are proud of theresults achieved during these twoFDA inspections. For this particularsuccess, the CSR team aligned itsskills and long experience in thescale-up, validation and commerciallaunch of APIs in collaboration withPompey, our centre of excellence forcGMP chromatographic purification.Novasep has a genuine know-how inbringing together top Europeanquality level services andtechnologies.”Registration now open for RDD ConferenceThe Respiratory Drug Delivery Asiascientific conference will welcomepulmonary and nasal drug delivery expertsfrom all over the world to Goa, India from12th to 14th November.Bringing the respiratory world togetherfor the first time in Asia, RDD scientificconferences are globally regarded as thepremier venue for presenting the latestadvances in pulmonary and nasal drugdelivery. The event takes place in Europeand the United States in alternate years.RDD Asia 2014 seeks to link Asianregulators, industrial and academic scientists, clinicians and business professionals with their internationalcounterparts, together working toward the goal of advancing inhaled and nasal drug therapy worldwide.More than 200 delegates from Asia and beyond are expected to attend the conference which will be held at theGoa Marriott Resort & Spa in India. The meeting is jointly managed by RDD Online and Aptar Pharma. Thescientific programme and online registration are available at www.rddonline.com/rddasia2014.Solar refrigerator to revolutionise internationalmedical aidDulas has launched a battery-free solar vaccinationrefrigerator which will revolutionise the storage andtransportation of vaccines and other essential medicalsupplies to remote locations across the world.The 132-litre capacity solar direct drive refrigerator ispowered directly by a solar array and uses innovativephase change material and insulation technology tomaintain a constant temperature without the need for abattery. The refrigerator incorporates ground-breakingthermal energy storage technology to maintain atemperature of between 2°C and 8°C in extended periodsof low or no sunshine.Guy Watson, Head of International Operations at Dulas,says, “Conventional solar vaccine refrigerators rely on an in-built battery to store the energy generated by an arrayof solar panels. The new technology removes the need for a battery by using innovative phase change materialand insulation technology to ensure the refrigerator can maintain a constant temperature for more than three dayswithout sunlight or external power.”Genea Biomedx opens atDiscovery ParkAustralian fertility group Genea has opened aresearch, manufacture and distribution base atDiscovery Park, in Sandwich, Kent.Genea’s IVF technologies company, Genea Biomedx,and stem cell researcher, Genea Biocells, are setting upheadquarters and facilities to manufacture culturemedium at the former Pfizer European headquarters,where they still have a presence, in order to access the growing European IVF and life sciences market. Kim Giliam, Genea Biomedx Commercial Director, says, “Discovery Park ticks all of the boxes. It’s close to allforms of transport to continental Europe as well as direct flights to North America and Asia. It makes sense for usto be here, making the vital solutions that nurture eggs, sperm and embryos during the IVF process locally andanswering the needs of IVF clinics across Europe.”44-49:Layout 1 25/7/14 09:38 Page 246Pharma Business International www.pbiforum.netLatest newsReduce production costings withSQC weighing systems The legal constraints faced bypharmaceutical companies on issuessuch as average weight legislation meanproducers often overfill bottles to ensuretheir final product does not fall below therequired specification. METTLER TOLEDOhas published a comprehensive guide toreducing overfilling to maximise theefficiency and profitability of yourproduction process.It also outlines how you can provecompliance with your governing body’srequirements using a Statistical QualityControl system. SQC weighing systemsapply statistical methods to processcontrol, accurately calculating mean andstandard deviation values to determine legally defined tolerance levels.The free guide outlines how an effective software package can improvereliability and productivity by monitoring, tracking and tracing your productionprocess. It also demonstrates how implementation of SQC solutions canincrease efficiency and profitability by minimising wastage throughout theproduction process. To order your copy of the free guide, visit www.mt.com/uk-ind-sqcguide.Recipharm and Pharmanest collaboratefor manufacture and supply of SHACTRecipharm Karlskoga andPharmanest have formed anew pharmaceuticalmanufacturing contract forSHACT.Every year, millions ofwomen around the worldexperience pain anddiscomfort during IUD insertion. There are few treatment options withproven efficacy and safety available to these women. SHACT is a productbased on an innovative formulation of lidocaine, a well-known anesthetic,and a proprietary application device developed to simplify topicalapplication in the cervix and uterus. SHACT has demonstrated convincingPhase II efficacy data as local anesthesia in connection with IUD insertionand also recently reported positive data from a hysteroscopy study.Ingela Palmkvist, General Manager at Recipharm in Karlskoga, picturedleft, says, “I really look forward to closely following the introduction of thisproduct to various markets. Indeed, I believe it will make a highlysignificant difference to patients.”Gunilla Lundmark, CEO at Pharmanest, pictured with Ingela, adds, “I Welook forward to working closely with Recipharm for the commercialmanufacture of the product and, indeed, to pooling our respective skills andcapabilities to supply the pharmaceutical product to key target markets.”EUROPEAN Seriest/FUXPSLXJUIJOEVTUSZQFFSTBOECVJMEOFXDPOUBDUTt7JTJUPWFSMFBEJOHTVQQMJFSTt4FFBOJNQSFTTJWFMJOFVQPGCSBOETBOEFYQFSUTJOBQSPHSBNNFPGGSFFMFBSO4IPQTt'JOEZPVSQFSGFDUPVUTPVSDJOHQBSUOFSBUUIF$POUSBDU1BDL'FBUVSF...PLUS lots more!Register for free at:www.easyFairs.com/PI-LondonSHOW SUPPORTERS1MFBTFSFGFSUPUIFXFCTJUFGPSBMMUIFTIPXTTVQQPSUFSTOFFICIAL MEDIA PARTNERThe future of branded and inspirational packaging$PMPDBUFEXJUIBusiness Design Centre, London 30 September & 1 October 2014 REGISTERNOW!To find out more about the show visit: www.easyFairs.com/PI-London0SHBOJTFECZ92% of visitors found their visit to be worthwhile80% of visitors identified a new supplier44-49:Layout 1 25/7/14 09:38 Page 3Pharma Business International 47www.pbiforum.netPHARMA BUSINESS INTERNATIONALPharmaceutical companies havealways reached for high standards, buttheir customers now often expect themto go above and beyond their legalrequirements to ensure absolute qualitybefore they award contracts. This meansmanufacturers need to ensure theirequipment and procedures are absolutelyexceptional.Although the investment in training andtechnology requires some short termexpenditure, the long term results can behugely impressive, with companies ableto compete at the very top level and bewell-placed to land major contracts. Themost successful companies in thepharmaceuticals sector are those whichhave benefited from innovation andinvestment in a high qualityinfrastructure.The pharmaceutical industry, like mostother manufacturing sectors, isconstantly in need of a steady stream ofnew talent, both to replace those whoare lost to the industry through retirementand to ensure employees are wellequipped with up to date knowledge oftheir roles and the industry as a whole.Initiatives such as the See InsideManufacturing scheme in the UK helpsachieve this by raising the profile ofmanufacturing and providing an excellentopportunity to identify new recruits – aswell as developing existing employeeswho get the opportunity to pass on theirskills.There are plenty of examples of howstronger links between businesses andeducational establishments are reapingthe rewards for employers andemployees alike. Many are workingtogether as part of Industrial CASEStudentships, to support cutting-edgeresearch into some of the currentpressing medical and biologicalchallenges.The studentships fund four-yearcollaborative PhD projects supervisedjointly by a member of academic staff48 Penn Pharma officially opened a new purpose-built containedmanufacturing facility last September and the training and subsequentcertification of its staff was a critical factor milestone to achieveExcellence assuredThe quest for high standards has ensured manufacturers are able to compete at the very top levelThe pharmaceutical industry, like most othermanufacturing sectors, is constantly in need of asteady stream of new talent44-49:Layout 1 25/7/14 09:38 Page 4PHARMA BUSINESS INTERNATIONAL48Pharma Business International www.pbiforum.netShows such as The Pharmacy Show arealso particularly valuable to allowthose working in the pharmaceuticalindustry to develop their skills44-49:Layout 1 25/7/14 09:38 Page 5Pharma Business International 49www.pbiforum.netPHARMA BUSINESS INTERNATIONALand an industrial partner. Studentships areprincipally based at the academic partner, with amandatory placement at the non-academic partnerfor a minimum of three and up to eighteen months.The University of Leicester has been awarded fourof these studentships, allowing businesses to takeadvantage of burgeoning medical and biologicalresearch talent.Among the studentships is a Medical ResearchCouncil CASE Studentship held jointly by Dr SimonWagner, of the Department of Cancer Studies andMolecular Medicine, and Domainex, the drugdiscovery company based in Cambridge. Buildingon the discovery of a potential survival pathway in acommon type of non-Hodgkin’s lymphoma, theproject will use novel agents developed byDomainex to understand the mechanism of thedrugs’ action and define patient groups that aremost likely to benefit.In one of the other studentships, Dr RichardBayliss and Professor Mark Carr from theDepartment of Biochemistry are working with MRCTechnology to develop an alternative approach tothe development of new drugs that block kinaseactivity, funded by the Biotechnology and BiologicalSciences Research Council. Protein kinases are themost frequently dysregulated family of proteins inhuman cancer. The project will investigate themechanisms by which the activity of an individualkinase molecule is controlled, and develop chemicalcompounds that block these processes. Thesemolecules will be developed into drug candidatesthrough the collaboration with MRCT.Dr Ismael Tejero, Business Development Managerin the University’s Enterprise and BusinessDevelopment Office, says, “These studentshipsprovide additional vocational skills not otherwiselearnt on a regular PhD and are great preparationfor both academic and industrial careers. They willalso help the University of Leicester to build morerelationships with industry and potentiallyencourage more collaborative work. Studentshipshelp to get the latest academic research transferredinto industry and are a great opportunity to collectfeedback about research and technology from ourindustrial partners.”While many companies are benefiting from newtalent, one of the major factors for a successfulcompany is ensuring that existing employees areable to adapt to the latest demands of the sector.Many pharmaceutical companies are thereforeinvesting in training and skills development to allowthem to react to the latest changes.Penn Pharma, for example, has completedpotent compound safety training and certificationfor its staff through Affygility Solutions. Thecompany officially opened a new purpose-builtcontained manufacturing facility last Septemberand the training and subsequent certification of itsstaff was a critical factor milestone to achieve.Penn Pharma selected Affygility Solutions tocomplete the training certification based on thespecific expertise they offer in potent compoundsafety. They also offered a unique and flexiblewebinar format allowing Penn Pharma staff toattend from multiple global locations. The trainingwas extremely comprehensive and includedIntroduction to potent compound safety, toxicology,industrial hygiene, banding and control strategies,as well as the manufacturing of highly potentcompounds including both understanding andcontrolling the risks.Mark Dean Netscher, Penn Pharma ChiefOperating Officer, says, “We are extremely pleasedto have our staff complete the potent compoundsafety training certification process. This is animportant component of our continued commitmentto employee safety and Operational Excellence inPenn as we continue to demonstrate leadership ofthe handling, development and manufacturing ofpotent products in our contained manufacturingfacility.”Shows such as The Pharmacy Show are alsoparticularly valuable to allow those working in thepharmaceutical industry to develop their skills. Atthe show, which takes place at the BirminghamNEC in September, there will be five educationprogrammes in total, featuring seminars andworkshop programmes will help both communityand hospital pharmacists run better, more profitablepharmacy businesses and establishments.Meanwhile, at the Keynote Theatre, key industryassociations, regulators as well as leading figuresfrom both independent and multiple organisationswill share their strategies for the future.Educational opportunities such as these meanthat pharmaceutical companies can benefit from asteady stream of informed and enthusedemployees – giving them a genuine competitiveadvantage.PHOTO: SHUTTERSTOCK.COM/MATEJ KASTELIC44-49:Layout 1 25/7/14 09:38 Page 6Next >